Cell to Cell Signaling

Cell to Cell Signaling

The system allows for the culturing of the same cell types, or different cell types, within an inter-connected network of wells. Effectively, this causes downstream cells to be exposed to the biological response of the upstream cells. Being a platform technology, it is a simple SOP change to include divergent cell lines or distinct primary cells within the system. A user may fill multiple wells with same cell type to create a concentration gradient of the parent chemical and metabolites across the row (each well and each row generates unique concentration gradient over the course of the experiment). Alternatively, multiple different cell types may be placed in adjacent wells, mimicking the path of the chemical through the human biological system (i.e. intestine to liver to target organ of choice).